Drugs

Patients can get independent information on drugs from the following (many track your IP address):
GENERAL:

• WorstPills.org ($15/year, cites many studies), side effects, advice and comparisons among drugs, run by Public Citizen
• MediGuard.org (free) is the only free place which shows interactions among all drugs you take or are considering (see UpToDate below for more detail). Run by Quintiles, which uses optional information from users to identify people for clinical trials
  
• Medical Letter (many citations, free trial with online access for 6 weeks, $10/article, $159/year or $98 for cumulative file from 1988 to previous December or June) Reviews new drugs and compares drugs and recommendations for common diseases. Some major diseases are listed as most read. Others are searchable as "drugs for". Comparable to UpToDate, which has cheap access but not free trials. More comparisons than GuideToPharmacology. French version for Canadian drugs comes out a few weeks after English version.
  
• UpToDate.com ($20/week, $45/month, detailed, many citations), recommendations for most conditions, interactions, side effects. Many doctors go here to get complete info and training.  Or if your doctor depends on drug company presentations (see below), you can get more information here than s/he has. Comparable to Medical Letter on drugs, which has free trial, but UpToDate also covers all medical approaches, not just drugs. More comparisons than Guide to Pharmacology. For major life decisions, people can check all three.
• AskaPatient.com (free, cites FDA), patient reviews, and FDA reports of adverse events, for over 4,000 drugs. Much easier than FDA. Ad-supported, not sponsored by drug companies.
• GuideToPharmacology.org (free, technical, many citations). Search "Ligands", which are bio-active drugs. For example if you type "statin" in the ligand search box and just wait without clicking anything, it will suggest Atorvorstatin, Lovastatin, and many more. Click on one to see chemical and clinical research about it. You can type brand names in the same search box.
• TRIPdatabase.com (free version or $40/year pro version) lets you search for primary research, or systematic reviews, or TRIP's own summaries, called "answers". Not just drugs, it covers all medical interventions, like UpToDate, but less thorough. TRIP says drug companies "do not have any editorial say in Trip".
• MedShadow.org (free, some citations), many articles on side effects and advice, and links to patient forums

SPECIALIZED

• DrugDangers.com (free) broad list of US lawsuits against makers of drugs and devices. It summarizes suits by the law firm which maintains it and other firms, though not giving other firms' names.
• Compare-Trials.org (free, full citations) Read some of their letters to see the poor quality of random trials in top medical journals.  Letters cover articles published October 2015 to January 2016 in NEJM, JAMA, Lancet, Annals of Internal Medicine, BMJ. (Also: 538, RetractionWatch, Guardian, Ioannidis, Gizmodo, Chocolate hoax)
  
• PubPeer.com (free, comments on citations), not specifically on drugs. It compiles comments on each published article, so if you find a significant article, you can check what others said about it.
• Drugs.com (free), factual, no comparisons, run by 2 pharmacists, supported by ads from drug companies and drug stores
• Consumer Reports Drugs (free, no citations), little information
  
• MedWhys.com (free, no citations), factual, lets you ask a pharmacist questions, which you can also do at most drug stores and hospital pharmacies
• ClinicalTrials.gov (free, technical, original data), shows random trials started, and results for a few (story on lack of results, and number of missing results by company and university)
• Mayo Clinic Shared Decision Making National Resource Center, (free, no citations). Graphs compare risk and benefit of drugs and other treatments for a few conditions (angina, heart attack, osteoporosis). Descriptions but no risk comparison for arthritis, depression, diabetes, and quitting smoking.
  

Cost and Number of Prescriptions, in Each State, from Each Doctor

You can find the number of drug prescriptions and costs in at least 2 places, described below. Both use Medicare data; prices can be somewhat different for patients with other insurance or none.

ProPublica has Medicare Part D cost for each drug: number of prescriptions and total spending. You can get separate totals for US and each state, so you can get average cost per prescription, and for each doctor who prescribed a drug 50 or more times in 2013.

Medicare itself has more complete Part D data. The US and state summary files (bottom of the link) show for each drug: the number of beneficiaries as well as prescriptions and spending, so you can get average per beneficiary (total during a year), as well as per prescription for each drug.

Medicare's detailed files show number of days prescribed, so you can get average cost of a daily dose, as well as each doctor who prescribed a drug 11 or more times in 2013. This info is in 23 million records, without state or US summaries. However you can get good state and national estimates by opening any of their 36 spreadsheets (divided by last name of prescriber) and getting averages there. The average costs do not vary much by last name of prescriber. (Tips for working with large spreadsheets)

Some doctors and drugs typically have 30-day or 90-day prescriptions, which may be renewed all year. Their averages include the cost for each  whole long prescription (30 or 90 days). Docs & drugs with shorter prescriptions only include that lower cost. Medicare's focus seems to be on cutting total costs, not cost per dose.

ProPublica's methodology says it has "retail cost" for these prescriptions.

Medicare's fact sheet gives more detail, saying it includes,

• The total drug cost includes the ingredient cost of the medication, dispensing fees, sales tax, and any applicable administration fees. It?s based on the amounts paid by the Part D plan, Medicare beneficiary, other government subsidies, and any other third-party payers (such as employers and liability insurers). Total drug costs do not reflect any manufacturer rebates paid to Part D plan sponsors.

It does not directly include patients' monthly premiums, though on average those premiums may cover all drugs, administration, and profits.

I'd be happy to hear of other sources, especially for younger patients.

After seeing which drugs a doctor prescribes, you can find drug safety and effectiveness from the sources at the top of the page.

Electronic Prescriptions

Most doctors send prescriptions to pharmacies electronically. This is more reliable than hand-written faxes, but two problems stand out:

• Most doctors cannot send, and most pharmacies cannot receive, electronic cancellation orders
• If the patient does not get a copy, the patient cannot check if the pharmacy filled it correctly.

Cancellation orders are crucial to correct mistakes and cancel refills. Patients can overdose when they keep getting the old medicine after the doctor orders a new one. Only a third of prescribers and 40% of pharmacies use software certified to handle cancellations, so less than a third of cancellations can go through. "Electronic health records allow prescribers to stop a prescription, but what many physicians may not realize is that in most cases that directive is not sent to any pharmacy," even though original prescriptions are reliably sent.

Health systems like the Veterans Health Administration and Kaiser Permanente, where prescriber and pharmacy are in the same organization, can cancel electronically. Otherwise only 5 pharmacy chains accept e-cancellations: 

• CVS/Caremark (which handles 23% of US prescriptions),
• ExpressScripts (12%),
• RiteAid (6%), 
• Kroger (3%),
• Wegmans (under 1%). 

Many non-chain pharmacies accept e-cancellation if they use one of 14 software systems listed with a † You can ask the pharmacy which software they use.

No other chain is certified for e-cancellation, such as Walgreens (16% of US prescriptions) and Walmart (7%). Consumer Reports unfortunately recommends Costco and Sam's Club for price (uncertified), Walgreens for its apps (uncertified), and supermarket chains for convenience (only Kroger's is certified). CR should know better.

Doctors can cancel electronically only if their software is certified under "Cancel Rx". Out of 920 systems, only 80 are marked as certified, and usually only the latest updates. If your doctor is part of a large group, you can ask the group to ensure its software gets certified and updated. Individual doctors have little control.

Automatic refills are even more dangerous. When pharmacies call patients to say, "Your prescription is ready," patients and callers do not know whether the doctor recently ordered it or it is a zombie renewal. Costco, CVS, RiteAid and Walgreens encourage patients to sign up for automatic refills, so patients at Costco and Walgreens (two which lack e-cancellations) can get undesired medicine for long periods, thinking their doctor ordered it.

Drug Companies Influence Doctors